TITLE: Application of FDA-Approved Memantine and Newer NitroMemantine Derivatives to Treat Neurological Manifestations in Rodent Models of Tuberous Sclerosis Complex PRINCIPAL INVESTIGATOR:

AWARD NUMBER: W81XWH-14-1-0068 TITLE: Defining Translational Reprogramming in Tuberous Sclerosis Complex PRINCIPAL INVESTIGATOR:

A Patient with Tuberous Sclerosis Complex and Spinal Muscular Atrophy; A Case Report

Background Tuberous Sclerosis Complex (TSC), and Spinal Muscular Atrophy (SMA) are two inherited disorders while they are genetically independent. TSC is characterized by the formation of multiple hamartomas in nearly all organs. SMA is a destructive neurological disorder leading to progressive muscular weakness and atrophy. Case Presentation</e...

Neurological and neuropsychiatric aspects of tuberous sclerosis complex.

Tuberous sclerosis (also known as tuberous sclerosis complex [TSC]) is a multisystem genetic disorder that affects almost every organ in the body. Mutations in the TSC1 or TSC2 genes lead to disruption of the TSC1-TSC2 intracellular protein complex, causing overactivation of the mammalian target of rapamycin (mTOR) protein complex. The surveillance and management guidelines and clinical criteri...

Tuberous Sclerosis presenting as a case of Obsessive Compulsive Disorder (OCD) : a rare presentation

Tuberous sclerosis is a complex neurological disorder with epilepsy, mental retardation, dermatological and neurological manifestations. Here we present a rare case where tuberous sclerosis presented as a case of obsessive compulsive disorder and the diagnosis of tuberous sclerosis was made on investigation and examination.

Award Number: W81XWH-11-1-0252 TITLE: Role of Altered mGluR Activity in Cognitive Impairments in TSC: Implications for a Novel Method of Treatment PRINCIPAL INVESTIGATOR: